IGHM antibody (Immunoglobulin Heavy Constant mu)

Details for Product anti-IGHM Antibody No. ABIN6297767
Antigen
  • AI326478
  • Igh-6
  • Igh-M
  • Igh6
  • Igm
  • muH
  • ighm1
  • wu:fj14a08
  • zgc:101769
  • AGM1
  • MU
  • VH
  • immunoglobulin heavy constant mu
  • Ighm
  • ighm
  • IGHM
Reactivity
Human
70
1
1
1
Host
Mouse
53
18
Clonality
Monoclonal
Conjugate
This IGHM antibody is un-conjugated
1
Application
Immunohistochemistry (IHC)
57
37
30
28
24
12
7
6
4
1
Options
Purpose Mouse anti-Human IgM Antibody [IHC only]
Immunogen The Mu heavy chain of human Ig was used as the immunogen for the Anti-IgM antibody.
Specificity Cytoplasm, cell surface and secreted
Purification The Mu heavy chain of human Ig was used as the immunogen for the Anti-IgM antibody.
Plasmids, Primers & others Plasmids, Primers & others IGHM products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Immunoglobulin heavy constant mu
Background

Target Description: Recognizes a protein of 75 kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. This mAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

Gene Symbol: IGHM

Gene ID 3507
UniProt P01871
Application Notes Prediluted format : incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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