Major Histocompatibility Complex, Class II, DQ alpha 1 (HLADQA1) antibody

Details for Product No. ABIN6297784
Antigen
  • CD
  • CELIAC1
  • DQ-A1
  • GSE
  • HLA-DQA
  • BoLA-DQA
  • hla-dqa1
  • major histocompatibility complex, class II, DQ alpha 1
  • major histocompatibility complex, class II, DQ alpha, type 1
  • major histocompatibility complex, class II, DQ alpha 1 L homeolog
  • HLA-DQA1
  • BOLA-DQA1
  • hla-dqa1.L
Reactivity
Human, Pig (Porcine)
99
16
13
1
Host
Mouse
91
8
Clonality
Monoclonal
Conjugate
Un-conjugated
10
7
7
4
4
4
3
3
3
3
3
3
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
74
54
41
19
11
3
2
2
1
Options
Purpose Mouse anti-Human/Pig HLA-DQ Antibody (MHC II) [Sodium Azide Free]
Immunogen The T4-positive CTL clone HG-38 was used as the immunogen for the HLA-DQ antibody.
Specificity Cell surface
Purification The T4-positive CTL clone HG-38 was used as the immunogen for the HLA-DQ antibody.
Antigen
Alternative Name HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1 Antibody Abstract)
Background

Target Description: Recognizes a DQ antigen, which is a dimer of 60 kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.

Gene Symbol: HLA-DQA1///HLA-DQB1///HLA-DQB

UniProt P01909, P01920
Pathways TCR Signaling, Cancer Immune Checkpoints
Application Notes Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (Frozen): 0.5-1 μg/mL for 30 min at RT (1)
Restrictions For Research Use only
Buffer In 1X PBS, BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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