HLA-DQA1 antibody

Catalog No. ABIN7260259

Product Details anti-HLA-DQA1 Antibody

Target: HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ alpha 1 (HLA-DQA1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HLA-DQA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human HLA-DQA1 (NP_002113.2).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000 IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for HLA-DQA1

Target: HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ alpha 1 (HLA-DQA1))

Alternative Name: HLA-DQA1 (HLA-DQA1 Products)

Synonyms: CD antibody, CELIAC1 antibody, DQ-A1 antibody, GSE antibody, HLA-DQA antibody, BoLA-DQA antibody, hla-dqa1 antibody, major histocompatibility complex, class II, DQ alpha 1 antibody, major histocompatibility complex, class II, DQ alpha, type 1 antibody, major histocompatibility complex, class II, DQ alpha 1 L homeolog antibody, HLA-DQA1 antibody, BOLA-DQA1 antibody, hla-dqa1.L antibody

Background: HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.

Molecular Weight:

Observed_MW: 28 kDa-37KD

Calculated_MW: 27 kDa

Gene ID: 3117

UniProt: P01909

Pathways: TCR Signaling, Cancer Immune Checkpoints