Calreticulin antibody (CALR)

Details for Product anti-CALR Antibody No. ABIN6297851
Antigen
  • CRT
  • RO
  • SSA
  • cC1qR
  • crc
  • crt
  • Calregulin
  • CG9429
  • Clr
  • Dmel\\CG9429
  • anon-EST:Liang-2.11
  • anon-EST:Liang-2.17
  • anon-EST:fe3D7
  • clone 2.11
  • clone 2.17
  • eth
  • potp
  • cc1qr
  • ssa
  • NV19007
  • CRP55
  • ERp60
  • HACBP
  • calrl2
  • fc66d10
  • wu:fc66d10
  • wu:fj50c03
  • zgc:66153
  • calreticulin
  • calreticulin L homeolog
  • Calreticulin
  • putative calreticulin
  • CALR
  • calr.L
  • Crt
  • crt
  • CRT
  • Calr
  • calr
  • LMJF_31_2600
  • Crc
  • LOC8269812
Reactivity
Human, Mouse (Murine)
278
160
128
46
42
41
41
40
39
36
31
31
8
6
3
2
1
1
1
1
Host
Rabbit
239
39
14
3
1
Clonality
Polyclonal
Conjugate
This Calreticulin antibody is un-conjugated
20
15
14
7
6
6
4
4
4
4
4
4
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
248
144
123
63
61
60
47
33
14
13
11
5
4
2
1
1
1
1
1
Options
Purpose Rabbit Anti-CALR Antibody
Immunogen This CALR Antibody is generated from rabbits immunized with a recombinant protein of human CALR.
Plasmids, Primers & others Plasmids, Primers & others Calreticulin products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name CALR (CALR Antibody Abstract)
Background

Target Description: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.

Gene Symbol: CALR

Gene ID 811
UniProt P27797
Pathways Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded protein response
Restrictions For Research Use only
Storage 4 °C,-20 °C
Storage Comment 2-8°C (short-term), -20°C (long-term)
Did you look for something else?