PTPN1 antibody (Protein tyrosine Phosphatase, Non-Receptor Type 1)

Details for Product anti-PTPN1 Antibody No. ABIN6297878
Antigen
  • PTPN1
  • PTP1B
  • PTP-1B
  • PTP-HA2
  • Ptp
  • ptp1b
  • wu:fk54h03
  • CPTP1
  • protein tyrosine phosphatase, non-receptor type 1
  • protein tyrosine phosphatase, non-receptor type 1 L homeolog
  • PTPN1
  • Ptpn1
  • ptpn1
  • ptpn1.L
Reactivity
Human, Mouse (Murine)
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122
83
25
17
10
7
6
3
2
2
1
1
Host
Rabbit
186
43
4
2
2
Clonality
Polyclonal
Conjugate
This PTPN1 antibody is un-conjugated
10
6
5
5
5
5
5
5
5
5
5
4
1
1
1
1
1
1
1
1
Application
192
109
68
30
27
23
13
11
11
7
3
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2
Options
Purpose Rabbit Anti-PTP1B Antibody
Immunogen This PTP1B antibody is generated from rabbits immunized with a recombinant protein encoding aa 1~321 of human PTP1B.
Plasmids, Primers & others Plasmids, Primers & others PTPN1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name PTP1B (PTPN1 Antibody Abstract)
Background

Target Description: PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.

Gene Symbol: PTPN1

Gene ID 5770
UniProt P18031
Pathways TLR Signaling, Response to Growth Hormone Stimulus, ER-Nucleus Signaling, Platelet-derived growth Factor Receptor Signaling
Restrictions For Research Use only
Storage 4 °C,-20 °C
Storage Comment 2-8°C (short-term), -20°C (long-term)
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