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GABA B Receptor antibody Primary Antibody

Reactivity: Human, Mouse, Rat Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6297919
$487.30
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 6 to 8 Business Days
  • Target
    GABA B Receptor
    Reactivity
    Human, Mouse, Rat
    • 11
    • 10
    • 10
    • 1
    • 1
    • 1
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    Un-conjugated
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Please inquire
    Purpose
    Rabbit Anti-GABA-B Receptor Antibody,
  • Restrictions
    For Research Use only
  • Storage
    4 °C,-20 °C
    Storage Comment
    2-8°C (short-term), -20°C (long-term)
  • Target
    GABA B Receptor
    Alternative Name
    GABA-B Receptor ()
    Background

    Target Description: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen.

    Gene Symbol: GABBR1

    Gene ID
    2550
    UniProt
    Q9UBS5
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