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EGF antibody

EGF Reactivity: Human, Mouse, Rat Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6298110
  • Target See all EGF Antibodies
    EGF (Epidermal Growth Factor (EGF))
    Reactivity
    • 142
    • 83
    • 49
    • 12
    • 11
    • 5
    • 4
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 208
    • 29
    • 9
    • 2
    • 2
    • 1
    Rabbit
    Clonality
    • 213
    • 37
    Polyclonal
    Conjugate
    • 108
    • 36
    • 19
    • 14
    • 11
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This EGF antibody is un-conjugated
    Application
    Please inquire
    Purpose
    Rabbit Anti-EGFR (Ab-1172) Antibody,
    Top Product
    Discover our top product EGF Primary Antibody
  • Restrictions
    For Research Use only
  • Storage
    4 °C,-20 °C
    Storage Comment
    2-8°C (short-term), -20°C (long-term)
  • Target
    EGF (Epidermal Growth Factor (EGF))
    Alternative Name
    EGF (EGF Products)
    Synonyms
    HOMG4 antibody, URG antibody, AI790464 antibody, CEGF antibody, epidermal growth factor antibody, pro-epidermal growth factor antibody, EGF antibody, egf antibody, CpipJ_CPIJ020278 antibody, Egf antibody
    Background

    Target Description: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.

    Gene Symbol: EGFR

    Gene ID
    1956
    UniProt
    P00533
    Pathways
    NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation
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