EGF antibody (Epidermal Growth Factor)

Details for Product anti-EGF Antibody No. ABIN6298110
Antigen
  • HOMG4
  • URG
  • AI790464
  • CEGF
  • epidermal growth factor
  • pro-epidermal growth factor
  • EGF
  • egf
  • CpipJ_CPIJ020278
  • Egf
Reactivity
Human, Mouse (Murine), Rat (Rattus)
383
168
95
19
17
9
4
2
1
1
1
1
Host
Rabbit
377
143
29
9
6
2
Clonality
Polyclonal
Conjugate
This EGF antibody is un-conjugated
58
25
21
11
11
9
7
7
7
7
7
7
4
4
4
4
4
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
389
279
129
66
54
33
29
29
28
25
22
19
14
7
5
4
4
3
2
1
1
Options
Purpose Rabbit Anti-EGFR (Ab-1172) Antibody,
Plasmids, Primers & others Plasmids, Primers & others EGF products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name EGF (EGF Antibody Abstract)
Background

Target Description: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.

Gene Symbol: EGFR

Gene ID 1956
UniProt P00533
Pathways NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation
Restrictions For Research Use only
Storage 4 °C,-20 °C
Storage Comment 2-8°C (short-term), -20°C (long-term)
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