BUB1B antibody (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast))

Details for Product anti-BUB1B Antibody No. ABIN6298121
Antigen
  • BUB1beta
  • BUBR1
  • Bub1A
  • MAD3L
  • MVA1
  • SSK1
  • hBUBR1
  • AU045529
  • bub1b
  • BUB1
  • BUB1-like
  • BubR1
  • BubRI
  • CG14030
  • CG14030/Bub1
  • Dmel\\CG14030
  • bub1
  • BUB1 mitotic checkpoint serine/threonine kinase B
  • BUB1B, mitotic checkpoint serine/threonine kinase
  • BUB1B, mitotic checkpoint serine/threonine kinase L homeolog
  • Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
  • Bub1 kinase
  • BUB1B
  • Bub1b
  • bub1b.L
  • bub1b
  • Bub1
Reactivity
Human, Mouse (Murine)
164
67
21
9
2
Host
Rabbit
94
70
12
Clonality
Polyclonal
Conjugate
This BUB1B antibody is un-conjugated
6
4
4
3
3
3
3
3
3
2
2
2
1
1
1
1
1
Application
139
75
59
51
33
14
13
12
11
6
4
4
3
3
2
2
1
Options
Purpose Rabbit Anti-BUB1B Antibody,
Plasmids, Primers & others Plasmids, Primers & others BUB1B products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name BUB1B (BUB1B Antibody Abstract)
Background

Target Description: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.

Gene Symbol: BUB1B

Gene ID 701
UniProt O60566
Restrictions For Research Use only
Storage 4 °C,-20 °C
Storage Comment 2-8°C (short-term), -20°C (long-term)
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