FEN1 antibody (Flap Structure-Specific Endonuclease 1)

Details for Product anti-FEN1 Antibody No. ABIN6298330
Antigen
  • FEN-1
  • FEN1
  • AW538437
  • MF1
  • RAD2
  • cb879
  • fen-1
  • fen1
  • mf1
  • rad2
  • xFEN1a
  • flap structure-specific endonuclease 1
  • flap endonuclease 1-like
  • Flap endonuclease-1
  • 5'-3' exonuclease family protein
  • flap structure specific endonuclease 1
  • flap structure-specific endonuclease 1 L homeolog
  • nuclease, Rad2 family
  • FEN1
  • LOC100808044
  • Bm1_49605
  • AT5G26680
  • Fen1
  • fen1
  • fen1.L
Reactivity
Human, Mouse (Murine), Rat (Rattus)
131
76
70
7
7
6
6
6
4
4
4
3
1
1
1
Host
Rabbit
102
29
Clonality
Polyclonal
Conjugate
This FEN1 antibody is un-conjugated
3
3
3
3
3
3
3
1
1
1
1
1
1
1
Application
105
37
30
27
18
18
13
10
7
3
3
2
1
Options
Purpose Rabbit Anti-FEN1 Antibody,
Plasmids, Primers & others Plasmids, Primers & others FEN1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name FEN1 (FEN1 Antibody Abstract)
Background

Target Description: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

Gene Symbol: FEN1

Gene ID 2237
UniProt P39748
Pathways Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA
Restrictions For Research Use only
Storage 4 °C,-20 °C
Storage Comment 2-8°C (short-term), -20°C (long-term)
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