ATP2A2 antibody (ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2)

Details for Product anti-ATP2A2 Antibody No. ABIN6566473
Antigen
Reactivity
Mouse (Murine), Rat (Rattus)
72
45
43
7
5
4
4
4
4
3
3
2
2
2
2
1
1
1
1
Host
Rabbit
73
1
1
Clonality
Polyclonal
Conjugate
This ATP2A2 antibody is un-conjugated
5
3
3
2
2
2
2
2
2
2
2
2
Application
Western Blotting (WB)
62
34
17
13
4
3
3
2
1
1
Options
Immunogen Recombinant protein of human ATP2A2
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name ATP2A2 (ATP2A2 Antibody Abstract)
Background

Synonyms: AT2A2,Atp2a2,ATP2B,ATPase Ca++ transporting cardiac muscle slow twitch 2,Calcium pump 2,Calcium-transporting ATPase sarcoplasmic reticulum type,Calcium-transporting ATPase sarcoplasmic reticulum type slow twitch skeletal muscle isoform,Cardiac Ca2+ ATPase,DAR,DD,Endoplasmic reticulum class 1/2 Ca(2+) ATPase,MGC45367,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,SERCA 2,SERCA2,serca2a,slow twitch skeletal muscle isoform,SR Ca(2+)-ATPase 2

Background: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight

Observed_MW: 115kDa

Calculated_MW: 109kDa/111kDa/114kDa

Gene ID 488
UniProt P16615
Pathways Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Ribonucleoside Biosynthetic Process
Application Notes WB 1:500 - 1:2000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) antibody (ABIN6566473) Western blot analysis of extracts of various cell lines, using ATP2A2 antibody.