RAD50 antibody (RAD50 Homolog (S. Cerevisiae))

Details for Product anti-RAD50 Antibody No. ABIN6566489
Antigen
Reactivity
Human, Mouse (Murine)
106
78
47
5
5
4
3
3
2
2
1
1
1
1
1
Host
Rabbit
108
19
2
Clonality
Polyclonal
Conjugate
This RAD50 antibody is un-conjugated
10
3
3
3
3
3
3
3
3
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
110
44
38
34
12
9
8
7
4
2
1
1
1
1
Options
Immunogen A synthetic peptide of human RAD50
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name RAD50 (RAD50 Antibody Abstract)
Background

Synonyms: DNA repair protein RAD50,hRAD50,hsRAD50,Mrell,NBSLD,Rad 50,RAD50 2,rad50,RAD50 homolog (S cerevisiae),RAD50 homolog,RAD50 PEN,RAD50,S. cerevisiae,homolog of,RAD50,RAD502,Rad50l,Truncated RAD50 protein

Background: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.

Molecular Weight

Observed_MW: 180kDa

Calculated_MW: 138kDa/153kDa/154kDa

Gene ID 10111
UniProt Q92878
Pathways DNA Damage Repair, Protein targeting to Nucleus
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-RAD50 Homolog (S. Cerevisiae) (RAD50) antibody (ABIN6566489) Western blot analysis of extracts of various cell lines, using RAD50 antibody.
Image no. 2 for anti-RAD50 Homolog (S. Cerevisiae) (RAD50) antibody (ABIN6566489) Immunohistochemistry of paraffin-embedded human gastric cancer using RAD50 Antibody.
Image no. 3 for anti-RAD50 Homolog (S. Cerevisiae) (RAD50) antibody (ABIN6566489) Immunohistochemistry of paraffin-embedded human uterine cancer using RAD50 Antibody.
Image no. 4 for anti-RAD50 Homolog (S. Cerevisiae) (RAD50) antibody (ABIN6566489) Immunohistochemistry of paraffin-embedded human breast cancer using RAD50 Antibody.