Synonyms: ALS,ALS1,Amyotrophic lateral sclerosis 1 adult,Cu/Zn SOD,Cu/Zn superoxide dismutase,Epididymis secretory protein Li 44,HEL S 44,Homodimer,hSod1,Indophenoloxidase A,IPOA,Mn superoxide dismutase,SOD,SOD soluble,SOD1,SOD2,SODC,SODC,Superoxide dismutase [Cu-Zn],Superoxide dismutase 1,Superoxide dismutase 1 soluble,Superoxide dismutase Cu Zn,Superoxide dismutase cystolic
Background: The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.