VEGFA antibody (Vascular Endothelial Growth Factor A)

Details for Product anti-VEGFA Antibody No. ABIN6566558
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
322
153
143
35
32
28
20
14
7
5
4
4
4
4
3
3
3
3
1
1
1
Host
Rabbit
301
118
19
1
1
1
1
Clonality
Polyclonal
Conjugate
This VEGFA antibody is un-conjugated
57
31
14
4
4
4
4
4
4
4
4
4
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
321
197
105
70
43
27
26
25
18
16
16
15
13
12
8
6
4
4
1
1
1
1
Options
Immunogen A synthetic peptide of human VEGFA
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name VEGFA (VEGFA Antibody Abstract)
Background

Synonyms: Folliculostellate cell-derived growth factor,Glioma-derived endothelial cell mitogen,MGC70609,MVCD1,Vascular endothelial growth factor A,vascular endothelial growth factor A121,vascular endothelial growth factor A165,vascular endothelial growth factor,Vascular permeability factor,VEGF A,Vegf,VEGF-A,VEGF120,Vegfa,VEGFA,VPF

Background: This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.

Molecular Weight

Observed_MW: 16-45kDa

Calculated_MW: 15-27kDa/34-45kDa

Gene ID 7422
UniProt P15692
Pathways RTK Signaling, Glycosaminoglycan Metabolic Process, Regulation of Cell Size, Tube Formation, Signaling Events mediated by VEGFR1 and VEGFR2, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals, VEGF Signaling
Application Notes WB 1:500 - 1:2000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Vascular Endothelial Growth Factor A (VEGFA) antibody (ABIN6566558) Western blot analysis of extracts of various cell lines, using VEGFA antibody.