JNK antibody (Mitogen-Activated Protein Kinase 8)

Details for Product anti-MAPK8 Antibody No. ABIN6566563
Antigen
Reactivity
Human, Mouse (Murine)
431
196
176
21
17
12
9
6
6
3
2
2
2
1
1
1
1
Host
Rabbit
350
91
3
2
Clonality
Polyclonal
Conjugate
This JNK antibody is un-conjugated
22
16
15
11
11
11
7
7
7
7
7
7
3
3
3
3
3
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
329
209
122
79
71
57
39
38
21
19
18
7
4
4
3
3
2
1
1
1
1
1
Options
Immunogen Recombinant protein of human MAPK8
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name JNK1 (MAPK8 Antibody Abstract)
Background

Synonyms: AI849689,c Jun N terminal kinase 1,C-JUN kinase 1,c-Jun N-terminal kinase 1,EC 2.7.11.24,JNK 1,JNK,JNK-46,JNK1A2,JNK21B1/2,MAP kinase 8,MAPK 8,mapk8,Mitogen activated protein kinase 8,Mitogen-activated protein kinase 8,MK08,p54 gamma,Prkm8,Protein kinase JNK1,Protein kinase,mitogen-activated,8,SAPK 1,SAPK gamma,SAPK1,Stress-activated protein kinase 1,Stress-activated protein kinase JNK1

Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

Molecular Weight

Observed_MW: 50kDa

Calculated_MW: 35kDa/44kDa/48kDa

Gene ID 5599
UniProt P45983
Pathways MAPK Signaling, WNT Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor
Application Notes WB 1:500 - 1:2000 IHC 1:100 - 1:200
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Mitogen-Activated Protein Kinase 8 (MAPK8) antibody (ABIN6566563) Western blot analysis of extracts of various cell lines, using MAPK8 antibody.
Image no. 2 for anti-Mitogen-Activated Protein Kinase 8 (MAPK8) antibody (ABIN6566563) Immunohistochemistry of paraffin-embedded human colon using MAPK8 antibody.