TNFRSF1B antibody (Tumor Necrosis Factor Receptor Superfamily, Member 1B)

Details for Product anti-TNFRSF1B Antibody No. ABIN6566586
Antigen
Reactivity
Human
179
117
67
6
3
2
2
2
2
2
2
Host
Rabbit
155
57
15
7
4
1
1
Clonality
Polyclonal
Conjugate
This TNFRSF1B antibody is un-conjugated
31
12
4
3
3
3
3
3
3
2
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
162
95
69
66
60
32
29
25
21
18
14
9
6
4
3
2
1
1
1
1
Options
Immunogen Recombinant protein of human TNFRSF1B
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name TNFRSF1B (TNFRSF1B Antibody Abstract)
Background

Synonyms: CD120b,p75,p75 TNF receptor,p75TNFR,p80 TNF alpha receptor,p80 TNF-alpha receptor,Soluble TNFR1B variant 1,TBP-2,TBPII,TNF R II,TNF R2,TNF R75,TNF-R2,TNF-RII,TNFBR,TNFR-II,TNFR1B,TNFR2,TNFR80,TNFRII,Tnfrsf1b,TNR1B,Tumor necrosis factor beta receptor,Tumor necrosis factor receptor 2,Tumor necrosis factor receptor superfamily member 1B,Tumor necrosis factor receptor type II,Tumor necrosis factor-binding protein 2

Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
Molecular Weight

Observed_MW: 65kDa

Calculated_MW: 28kDa/48kDa
Gene ID 7133
UniProt P20333
Pathways NF-kappaB Signaling, Apoptosis, Cellular Response to Molecule of Bacterial Origin, Hepatitis C
Application Notes WB 1:500 - 1:2000 IF 1:50 - 1:200
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) antibody (ABIN6566586) Immunofluorescence analysis of U2OS cells using TNFRSF1B antibody.
Image no. 2 for anti-Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) antibody (ABIN6566586) Western blot analysis of extracts of THP-1 cells, using TNFRSF1B antibody.