Synonyms: CD120b,p75,p75 TNF receptor,p75TNFR,p80 TNF alpha receptor,p80 TNF-alpha receptor,Soluble TNFR1B variant 1,TBP-2,TBPII,TNF R II,TNF R2,TNF R75,TNF-R2,TNF-RII,TNFBR,TNFR-II,TNFR1B,TNFR2,TNFR80,TNFRII,Tnfrsf1b,TNR1B,Tumor necrosis factor beta receptor,Tumor necrosis factor receptor 2,Tumor necrosis factor receptor superfamily member 1B,Tumor necrosis factor receptor type II,Tumor necrosis factor-binding protein 2
Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.