Synonyms: BP 2,BP2,IBP 2,IBP-2,IBP2,IBP2,IGF binding protein 2,IGF BP53,IGF-binding protein 2,IGFBP 2,IGFBP-2,IGFBP2,IGFBP53,Insulin like growth factor binding protein 2 36 kDa,Insulin like growth factor binding protein 2,Insulin like growth factor-binding protein 2 precursor ,Insulin-like growth factor-binding protein 2
Background: The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene.