GEN1 antibody (Gen Endonuclease Homolog 1 (Drosophila))

Details for Product anti-GEN1 Antibody No. ABIN6566734
Antigen
Reactivity
Human, Mouse (Murine)
37
29
15
Host
Rabbit
37
Clonality
Polyclonal
Conjugate
This GEN1 antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
24
14
13
3
1
Options
Immunogen Recombinant protein of human GEN1
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name GEN1 (GEN1 Antibody Abstract)
Background

Synonyms: DKFZp781F0986,Flap endonuclease GEN homolog 1,FLJ40869,GEN 1,Gen,Gen homolog 1 endonuclease (Drosophila),Gen homolog 1 endonuclease,GEN,GEN1

Background: This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants.

Molecular Weight

Observed_MW: 103kDa

Calculated_MW: 102kDa

Gene ID 348654
UniProt Q17RS7
Pathways DNA Damage Repair
Application Notes WB 1:500 - 1:2000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Gen Endonuclease Homolog 1 (Drosophila) (GEN1) antibody (ABIN6566734) Western blot analysis of extracts of various cell lines, using GEN1 antibody.