Glutamate Receptor 1 antibody (pSer831)

Catalog No. ABIN6658218

Supplier Product No.: 612-401-c82

Product Details anti-Glutamate Receptor 1 Antibody

Target: Glutamate Receptor 1 (GLUR1)

Binding Specificity: pSer831

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glutamate Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB)

Supplier Product No.: 612-401-c82

Supplier: Rockland

Purpose: GluR1 phospho S831 Antibody

Cross-Reactivity (Details): Anti-GluR1 pS831 Antibody is directed against rat GluR1.

Purification: The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-GluR1 pS831 Antibody was produced by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser 831.

Isotype: IgG

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:1000

Comment:

Anti-GluR1 pS831 (Rabbit) antibody is tested for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 100 kDa in size corresponding to the GluR1 protein phosphorylated at Ser 831 in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for Glutamate Receptor 1

Target: Glutamate Receptor 1 (GLUR1)

Alternative Name: GluR1 (GLUR1 Products)

Background:

Synonyms: Glutamate receptor 1, GluR1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1,

Background: GluR1 pS831 Antibody detects GluR1. The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR1 subunit is widely expressed throughout the nervous system. GluR1 is potentiated by phosphorylation at Ser 831 which has been shown to be mediated by either PKC or CaM kinase II. In addition, phosphorylation of this site has been linked to synaptic plasticity as well as learning and memory. Therefore, GluR1 pS831 antibody is ideal for investigators involved in Neuroscience.

Gene Name: GRIA1

Gene ID: 50592

NCBI Accession: NP_113796

UniProt: P19490

Pathways: PI3K-Akt Signaling