PD-L1 antibody (CD274 Molecule) (Biotin)

Details for Product anti-CD274 Antibody No. ABIN6727405
Target
Reactivity
Mouse
151
75
39
5
4
4
1
1
Host
Rat
97
55
17
9
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This PD-L1 antibody is conjugated to Biotin
16
14
10
9
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
92
83
66
51
22
14
13
10
10
9
7
4
4
3
2
2
2
1
1
1
Options
Clone 10F-9G2
Isotype IgG2b, kappa
Target
Alternative Name CD274/PD-L1 (CD274 Antibody Abstract)
Background

Synonyms: B7-H1, PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1

Background: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

Gene ID 60533
UniProt Q9EP73
Pathways Cancer Immune Checkpoints
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS with 0.05 % Proclin300, 1 % BSA
Preservative ProClin
Precaution of Use This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.