PD-L1 antibody (CD274 Molecule) (Biotin)

Details for Product anti-CD274 Antibody No. ABIN6727427
Antigen
  • B7-H
  • B7H1
  • PD-L1
  • PDCD1L1
  • PDCD1LG1
  • PDL1
  • A530045L16Rik
  • B7h1
  • Pdcd1l1
  • Pdcd1lg1
  • Pdl1
  • RGD1566211
  • CD274 molecule
  • CD274 antigen
  • programmed cell death 1 ligand 2
  • CD274
  • Cd274
  • PDCD1LG2
Reactivity
Human
264
114
55
7
5
4
1
1
Host
Mouse
168
101
24
10
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This PD-L1 antibody is conjugated to Biotin
22
17
14
12
6
5
5
5
5
5
4
3
2
2
1
1
1
1
1
Application
Flow Cytometry (FACS)
162
119
105
77
29
24
16
16
13
12
11
9
4
3
3
2
2
1
1
1
Options
Clone 29E-2A3
Isotype IgG2b, kappa
Plasmids, Primers & others Plasmids, Primers & others PD-L1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name CD274/PD-L1 (CD274 Antibody Abstract)
Background

Synonyms: B7-H1, PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1

Background: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

Gene ID 29126
UniProt Q9NZQ7
Pathways Cancer Immune Checkpoints
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS with 0.05 % Proclin300, 1 % BSA
Preservative ProClin
Precaution of Use This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.