Macrophage Mannose Receptor 1 antibody (Mannose Receptor, C Type 1) (PE)

Details for Product anti-MRC1 Antibody No. ABIN6727450
Antigen
  • CD206
  • CLEC13D
  • CLEC13DL
  • MMR
  • MRC1L1
  • bA541I19.1
  • AW259686
  • MR
  • mrc1
  • MGC86525
  • MRC1
  • MRC1L-A
  • mannose receptor C-type 1
  • mannose receptor, C type 1
  • mannose receptor C-type 1 L homeolog
  • mediator of replication checkpoint 1
  • MRC1
  • Mrc1
  • mrc1.L
  • mrc1
Reactivity
Mouse (Murine)
104
72
33
2
2
Host
Rat
77
36
26
Clonality (Clone)
Monoclonal ()
Conjugate
This Macrophage Mannose Receptor 1 antibody is conjugated to PE
12
11
8
6
3
3
3
2
2
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
85
50
46
29
21
21
17
16
12
10
8
8
5
1
1
Options
Clone C068C2
Isotype IgG2a, kappa
Plasmids, Primers & others Plasmids, Primers & others Macrophage Mannose Receptor 1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name CD206 (MRC1 Antibody Abstract)
Background

Synonyms: MMR,MR,MRC1,macrophage mannose receptor,mannose receptor

Background: CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.

Gene ID 17533
UniProt Q61830
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS with 0.05 % Proclin300, 1 % BSA
Preservative ProClin
Precaution of Use This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
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