FCER1A antibody (Fc Fragment of IgE, High Affinity I, Receptor For, alpha Polypeptide) (PE)

Details for Product anti-FCER1A Antibody No. ABIN6728427
Antigen
  • FCER1A
  • FCE1A
  • FcERI
  • Iger01
  • RATIGER01
  • Fce1a
  • Fcr-5
  • fcepsilonri
  • Fc fragment of IgE receptor Ia
  • Fc receptor, IgE, high affinity I, alpha polypeptide
  • FCER1A
  • Fcer1a
Reactivity
Mouse (Murine)
90
49
3
2
1
Host
Armenian Hamster
57
33
23
22
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This FCER1A antibody is conjugated to PE
15
13
10
5
3
3
2
2
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
98
59
44
27
17
13
9
9
6
3
2
2
1
1
Options
Clone MAR-1
Isotype IgG
Plasmids, Primers & others Plasmids, Primers & others FCER1A products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name FcepsilonRIalpha (FCER1A Antibody Abstract)
Background

Synonyms: High affinity immunoglobulin epsilon receptor subunit alpha,Fc-epsilon RI-alpha,FcERI,Fcer1a

Background: FcεRIα is a transmembrane protein belonging to the Ig superfamily. FcεRIα forms a tetrameric complex with one β and two γ-subunits. The FcεRI complex plays an important role in triggering IgE-mediated allergic reactions. It is abundantly expressed on mast and basophils and up-regulated by the presence of IgE. Following stimulation via FcεRIα, mast cells and basophils release bioactive chemical mediators such as histamine, resulting in the initiation of allergic reactions. Cross linking of the high-affinity receptor for IgE on tissue mast cells triggers immediate hypersensitivity with local symptoms. The MAR-1 monoclonal antibody reacts with the FcεRIα subunit.

Gene ID 14125
UniProt P20489
Pathways Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS with 0.05 % Proclin300, 1 % BSA
Preservative ProClin
Precaution of Use This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
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