IL-10 antibody (Interleukin 10) (PE)

Details for Product anti-IL10 Antibody No. ABIN6728559
Target
Reactivity
Mouse
185
104
62
17
17
11
10
8
7
7
6
5
5
4
3
3
2
2
1
1
Host
Rat
176
78
62
5
4
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This IL-10 antibody is conjugated to PE
42
20
13
12
10
7
3
3
3
3
3
3
3
3
3
3
3
1
1
1
Application
Flow Cytometry (FACS)
203
194
72
54
39
39
39
30
26
18
17
16
12
11
9
9
5
4
4
3
3
3
3
2
1
1
1
1
1
1
1
1
Options
Clone JES5-16E3
Isotype IgG2b, kappa
Target
Alternative Name IL-10 (IL10 Antibody Abstract)
Background

Synonyms: Interleukin-10,IL-10,Cytokine synthesis inhibitory factor,CSIF

Background: L-10 was originally described as Cytokine Synthesis Inhibitory Factor (CSIF) by virtue of its ability to inhibit cytokine production by Th1 clones. IL-10 shares over 80 % sequence homology with the Epstein-Barr virus protein BCRFI. IL-10 inhibits IFN-γ, TNF-β, and IL-2 production by Th1 clones, inhibits macrophage-mediated IL-1, IL-6, and TNF-α synthesis, suppresses the delayed type hypersensitivity response, stimulates Th2 cell response (which results in elevated antibody production), and promotes mast cell proliferation in combination with IL-4.

Gene ID 16153
UniProt P18893
Pathways Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location, Cancer Immune Checkpoints
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS with 0.05 % Proclin300, 1 % BSA
Preservative ProClin
Precaution of Use This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.