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IRF3 antibody (Interferon Regulatory Factor 3) (AA 51-150) (HRP) Primary Antibody

IRF3 Reactivity: Human, Mouse, Rat, Cow, Monkey ELISA, IHC (fro), IHC (p), WB Host: Rabbit Polyclonal HRP
Catalog No. ABIN682597
$442.20
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 11 to 16 Business Days
  • Target
    IRF3
    Binding Specificity
    • 16
    • 16
    • 14
    • 14
    • 13
    • 9
    • 8
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 51-150
    Reactivity
    • 144
    • 86
    • 53
    • 30
    • 18
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Monkey
    Host
    • 149
    • 15
    • 2
    Rabbit
    Clonality
    • 136
    • 30
    Polyclonal
    Conjugate
    • 93
    • 10
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This IRF3 antibody is conjugated to HRP
    Application
    • 113
    • 69
    • 39
    • 29
    • 27
    • 24
    • 20
    • 12
    • 11
    • 11
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Cross-Reactivity
    Cow, Dog, Horse, Pig
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human IRF3
    Isotype
    IgG
  • Application Notes
    WB 1:300-1000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
    Preservative
    Gentamicin sulfate
    Precaution of Use
    This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Storage
    4 °C
    Storage Comment
    Store at 4 °C
    Expiry Date
    12 months
  • Target
    IRF3
    Alternative Name
    IRF3 (IRF3 Antibody Abstract)
    Synonyms
    irf3, IRF3, C920001K05Rik, IRF-3, interferon regulatory factor 3, interferon regulatory factor 7, irf3, IRF3, irf-3, Irf3, IRF7
    Background

    Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

    Subcellular location: Cytoplasm, Nucleus

    Synonyms: Interferon regulatory factor 3, IRF-3, IRF3

    Gene ID
    3661
    UniProt
    Q14653
    Pathways
    TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
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