ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) (AA 1051-1280) antibody (HRP)

Catalog No. ABIN686986

Product Details

Target: ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B)

Binding Specificity: AA 1051-1280

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: HRP

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MDR1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C/-80 °C

Storage Comment: Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles

Expiry Date: 12 months

Target Details

Target: ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B)

Alternative Name: MDR1 (ABCB1B Products)

Synonyms: ABC20 antibody, CD243 antibody, CLCS antibody, GP170 antibody, MDR1 antibody, P-GP antibody, PGY1 antibody, Abcb1 antibody, Mdr1 antibody, Mdr1b antibody, Pgy-1 antibody, Pgy1 antibody, mdr antibody, ATP binding cassette subfamily B member 1 antibody, ATP-binding cassette, sub-family B (MDR/TAP), member 1B antibody, ATP-binding cassette, subfamily B (MDR/TAP), member 1B antibody, ABCB1 antibody, Abcb1b antibody

Background:

P Glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas.

Subcellular location: Cell membrane

Synonyms: P-Glycoprotein, Multi Drug Resistance Associated Protein, ABCB1, ATP-binding cassette sub-family B MDR/TAP, member 1, ABC20, CD243, CD243 antigen, CLCS, Multidrug resistance protein 1, P glycoprotein 1, p-GP, gp170, P gp, PGY1.

Gene ID: 5243