Neuregulin 1 antibody (NRG1) (AA 90-140) (Alexa Fluor 680)

Details for Product anti-NRG1 Antibody No. ABIN6944319
Antigen
  • 6030402G23Rik
  • ARIA
  • D230005F13Rik
  • GGF
  • GGFII
  • HRG
  • HRGalpha
  • Hgl
  • NDF
  • SMDF
  • GGF2
  • HGL
  • HRG1
  • HRGA
  • MST131
  • NRG-1
  • heregulin
  • nrg1-A
  • pro-neuregulin-1
  • NRG1
  • wu:fm70e01
  • DKFZp459A1838
  • neuregulin 1
  • neuregulin 1 L homeolog
  • Nrg1
  • NRG1
  • nrg1.L
  • nrg1
Epitope
AA 90-140
21
14
14
11
8
7
6
6
5
5
5
4
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
195
88
78
3
2
1
1
1
1
1
1
Host
Rabbit
201
17
Clonality
Polyclonal
Conjugate
This Neuregulin 1 antibody is conjugated to Alexa Fluor 680
18
8
6
5
5
4
4
4
4
4
3
3
3
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
155
79
72
37
22
21
15
13
11
8
7
5
3
2
2
1
1
Options
Immunogen KLH conjugated synthetic peptide derived from human Neuregulin-1
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others Neuregulin 1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name NRG1 (NRG1 Antibody Abstract)
Background

The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). The NRG-1 protein binds to and activates the tyrosine kinases receptors ErbB3 and ErbB4, initiating signaling cascades. NRG-1 has multiple functions, for example, in the brain it regulates various processes such as radial glia formation and neuronal migration, dendritic development, and expression of neurotransmitters receptors, in the peripheral nervous system NRG-1 regulates processes such as target cell differentiation, and Schwann cell survival.

Subcellular location: Extracellular


Synonyms: Acetylcholine receptor-inducing activity, ARIA, Breast cancer cell differentiation factor p45, GGF, Glial growth factor, Heregulin, HGL, HRG, HRG1, HRGA, NDF, Neu differentiation factor, Neuregulin1, NRG 1, Pro-neuregulin-1, membrane-bound isoform, Sensory and motor neuron-derived factor, SMDF, NRG1_HUMAN.
Gene ID 3084
UniProt Q02297
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
Application Notes IF(IHC-P)(1:50-200)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Expiry Date 12 months
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