Neuregulin 1 antibody (NRG1) (AA 90-140) (Alexa Fluor 680)

Details for Product anti-NRG1 Antibody No. ABIN6944319
Target
Binding Specificity
AA 90-140
12
12
11
9
7
6
4
4
4
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse, Rat
118
59
50
3
2
1
1
1
1
1
1
Host
Rabbit
124
13
Clonality
Polyclonal
Conjugate
This Neuregulin 1 antibody is conjugated to Alexa Fluor 680
15
6
5
4
3
3
3
3
3
2
2
2
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
105
63
55
26
21
14
11
11
10
7
7
5
3
2
2
2
1
Options
Immunogen KLH conjugated synthetic peptide derived from human Neuregulin-1
Isotype IgG
Purification Purified by Protein A.
Target
Alternative Name NRG1 (NRG1 Antibody Abstract)
Background

The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). The NRG-1 protein binds to and activates the tyrosine kinases receptors ErbB3 and ErbB4, initiating signaling cascades. NRG-1 has multiple functions, for example, in the brain it regulates various processes such as radial glia formation and neuronal migration, dendritic development, and expression of neurotransmitters receptors, in the peripheral nervous system NRG-1 regulates processes such as target cell differentiation, and Schwann cell survival.

Subcellular location: Extracellular


Synonyms: Acetylcholine receptor-inducing activity, ARIA, Breast cancer cell differentiation factor p45, GGF, Glial growth factor, Heregulin, HGL, HRG, HRG1, HRGA, NDF, Neu differentiation factor, Neuregulin1, NRG 1, Pro-neuregulin-1, membrane-bound isoform, Sensory and motor neuron-derived factor, SMDF, NRG1_HUMAN.
Gene ID 3084
UniProt Q02297
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
Application Notes IF(IHC-P)(1:50-200)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Expiry Date 12 months