Neuregulin 1 antibody (AA 21-242)

Catalog No. ABIN6939614

This Mouse Monoclonal antibody specifically detects Neuregulin 1 in ELISA and IF. It exhibits reactivity toward Human.

Quick Overview for Neuregulin 1 antibody (AA 21-242) (ABIN6939614)

Target: Neuregulin 1 (NRG1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Neuregulin 1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Clone: NRG1-2752

Product Details anti-Neuregulin 1 Antibody

Binding Specificity: AA 21-242

Purpose: Heregulin-1 / Neuregulin-1 (Breast and Urothelial Marker) Antibody

Specificity: Heregulin-1 is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human Neuregulin-1 (NRG1) protein (around aa 21-242) (exact sequence is proprietary)

Isotype: IgG

Application Details

Application Notes:

Positive Control: A431, MCF-7 or T47D cells. Breast, Bladder or Thyroid Carcinoma.

Known Application: ELISA (For coating, order Ab without BSA), Immunofluorescence (1-2 μg/mL)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Neuregulin 1

Target: Neuregulin 1 (NRG1)

Alternative Name: NRG1

Background:

Acetylcholine receptor-inducing activity (ARIA), Breast cancer cell differentiation factor p45, Glial growth factor (GGF2), Heregulin-1, Heregulin, alpha (45kD, ERBB2 p185-activator), HGL, HRG1, HRGA, MST131, Neu Differentiation Factor (NDF), Neuregulin-1, NRG1, Sensory and Motor Neuron-Derived Factor (SMDF)

A431, Bladder or Thyroid Carcinoma., MCF-7 or T47D cells. Breast

Molecular Weight: 26-71kDa

Gene ID: 3084, 453951, 668810

UniProt: Q02297

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation