P21-Activated Kinases 1/2/3 (PAK1/2/3) (pSer139), (pSer141), (pSer144) antibody

Details for Product No. ABIN6944410
Antigen
  • X-PAK1
  • XPak1
  • pak
  • pak-1
  • pakalpha
  • p21 protein (Cdc42/Rac)-activated kinase 1 S homeolog
  • p21 (RAC1) activated kinase 1
  • pak1.S
  • PAK1
Epitope
pSer139, pSer141, pSer144
27
19
17
16
16
14
6
5
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
89
62
61
1
1
1
Host
Rabbit
90
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
3
3
3
3
1
Application
Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (IHC), Western Blotting (WB)
52
37
30
14
10
3
2
2
2
1
1
Options
Immunogen Synthetic phospho-peptide surrounding S139+S141+S144 of PAK
Clone 9A3
Isotype IgG
Purification Purified by Protein A.
Antigen
Alternative Name PAK1, PAK2, PAK3 (PAK1/2/3 Antibody Abstract)
Background

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.


Synonyms: Serine/threonine-protein kinase PAK 1, Alpha-PAK, p21-activated kinase 1, p65-PAK, Serine/threonine-protein kinase PAK 2, Gamma-PAK, PAK65, S6/H4 kinase, p21-activated kinase 2, p58, Serine/threonine-protein kinase PAK 3, Beta-PAK, Oligophrenin-3, p21-activated kinase 3, PAK-1, PAK1, PAK-2, PAK2, PAK-3, PAK3
Gene ID 5063
UniProt O75914
Application Notes WB(1:300-1000), FCM(1:20-100), IF(ICC)(1:50-200), IHC()
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months
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