PD-L1 antibody (CD274 Molecule)

Details for Product anti-CD274 Antibody No. ABIN6944458
Target
Reactivity
Human
154
76
39
5
4
4
2
2
2
1
1
Host
Rabbit
100
55
18
9
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This PD-L1 antibody is un-conjugated
16
15
10
9
4
4
4
3
2
2
2
2
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Western Blotting (WB)
93
87
66
51
22
16
13
10
10
9
7
4
4
3
2
2
2
1
1
1
Options
Immunogen Recombinant human PD-L1 extracellular domain
Clone 6C8
Isotype IgG
Purification Purified by Protein A.
Target
Alternative Name PD-L1 (CD274 Antibody Abstract)
Background

Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).


Synonyms: Programmed cell death 1 ligand 1, CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1, Programmed death ligand 1
Gene ID 29126
UniProt Q9NZQ7
Pathways Cancer Immune Checkpoints
Application Notes WB(1:1000-2000), FCM(1:100-200)
Restrictions For Research Use only
Storage -20 °C
Storage Comment Store for 1 year at -20°C from date of shipment.