PD-L1 antibody (CD274 Molecule)

Details for Product anti-CD274 Antibody No. ABIN6944458
Antigen
  • B7-H
  • B7H1
  • PD-L1
  • PDCD1L1
  • PDCD1LG1
  • PDL1
  • A530045L16Rik
  • B7h1
  • Pdcd1l1
  • Pdcd1lg1
  • Pdl1
  • RGD1566211
  • CD274 molecule
  • CD274 antigen
  • programmed cell death 1 ligand 2
  • CD274
  • Cd274
  • PDCD1LG2
Reactivity
Human
266
114
55
7
5
4
1
1
Host
Rabbit
166
103
25
11
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This PD-L1 antibody is un-conjugated
22
18
14
12
6
5
5
5
5
5
4
3
2
2
1
1
1
1
1
Application
Flow Cytometry (FACS), Western Blotting (WB)
153
116
100
72
30
23
17
16
13
12
11
9
4
4
3
2
2
1
1
Options
Immunogen Recombinant human PD-L1 extracellular domain
Clone 6C8
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others PD-L1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name PD-L1 (CD274 Antibody Abstract)
Background

Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).


Synonyms: Programmed cell death 1 ligand 1, CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1, Programmed death ligand 1
Gene ID 29126
UniProt Q9NZQ7
Pathways Cancer Immune Checkpoints
Application Notes WB(1:1000-2000), FCM(1:100-200)
Restrictions For Research Use only
Storage -20 °C
Storage Comment Store for 1 year at -20°C from date of shipment.