The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity (referenced from entrez gene.
Subcellular location: Cytoplasm, Nucleus
Synonyms: LEM6, PGC-1 Alpha, PGC1 Alpha, Ligand effect modulator 6, Peroxisome prolerative activated receptor, gamma, coactivator 1 alpha, Peroxisome prolerative activated receptor, gamma, coactivator 1 , Peroxisome prolerator activated receptor gamma coactivator 1 alpha, PGC 1 alpha, PGC 1 alpha, PGC 1v, PGC1, PGC1alpha, PGC1A, PGC1v, PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6, PPAR gamma coactivator 1 alpha, PPAR gamma coactivator 1, PPAR gamma coactivator variant form, PPARGC 1 alpha, PPARGC1A.