PGC1 alpha + beta (AA 601-700) antibody (Alexa Fluor 680)

Catalog No. ABIN6944538

Product Details

Target: PGC1 alpha + beta

Binding Specificity: AA 601-700

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Alexa Fluor 680

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Specificity: 76 % homology with PGC1 beta

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PPARGC1A

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: PGC1 alpha + beta

Alternative Name: PGC1 alpha , beta

Synonyms: LEM6 antibody, PGC-1(alpha) antibody, PGC-1v antibody, PGC1 antibody, PGC1A antibody, PPARGC1 antibody, A830037N07Rik antibody, ENSMUSG00000079510 antibody, Gm11133 antibody, PGC-1 antibody, Pgc-1alpha antibody, Pgc1 antibody, Pgco1 antibody, Ppargc1 antibody, PPARG coactivator 1 alpha antibody, peroxisome proliferative activated receptor, gamma, coactivator 1 alpha antibody, PPARGC1A antibody, Ppargc1a antibody

Background:

Synonyms: LEM6, PGC-1 Alpha, PGC1 Alpha, Ligand effect modulator 6, Peroxisome prolerative activated receptor, gamma, coactivator 1 alpha, Peroxisome prolerative activated receptor, gamma, coactivator 1 , Peroxisome prolerator activated receptor gamma coactivator 1 alpha, PGC 1 alpha, PGC 1 alpha, PGC 1v, PGC1, PGC1alpha, PGC1A, PGC1v, PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6, PPAR gamma coactivator 1 alpha, PPAR gamma coactivator 1, PPAR gamma coactivator variant form, PPARGC 1 alpha, PPARGC1A.

Background: The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity (referenced from entrez gene.

Gene ID: 10891

UniProt: Q9UBK2