PGC1 alpha + beta antibody
Reactivity: Human, Mouse, Rat
WB
Host: Rabbit
Polyclonal
unconjugated
1 image
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- Target
- PGC1 alpha + beta
- Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- Un-conjugated
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Application
- Western Blotting (WB)
- Cross-Reactivity
- Mouse, Rat
- Purification
- Affinity purification
- Immunogen
- KLH conjugated Synthetic peptide corresponding to Human PGC1alpha+beta
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anti-PGC1 alpha + beta antibody
Reactivity: Human WB Host: Rabbit Monoclonal unconjugated
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- Application Notes
- WB (H,M,R) 1: 500-1: 1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS, pH 7.4, 0.02 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
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- Target
- PGC1 alpha + beta
- Synonyms
- LEM6 antibody, PGC-1(alpha) antibody, PGC-1v antibody, PGC1 antibody, PGC1A antibody, PPARGC1 antibody, A830037N07Rik antibody, ENSMUSG00000079510 antibody, Gm11133 antibody, PGC-1 antibody, Pgc-1alpha antibody, Pgc1 antibody, Pgco1 antibody, Ppargc1 antibody, PPARG coactivator 1 alpha antibody, peroxisome proliferative activated receptor, gamma, coactivator 1 alpha antibody, PPARGC1A antibody, Ppargc1a antibody
- Background
- PGC-1αis a transcriptional coactivator that regulates the genes involved in energy metabolism. It is the master regulator of mitochondrial biogenesis. This protein interacts with the nuclear receptor PPAR-γ, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element-binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor causing slow-twitch rather than fast-twitch muscle fiber types. Endurance exercise has been shown to activate the PGC-1α gene in human skeletal muscle. Exercise-induced PGC-1αin skeletal muscle increases autophagy and unfolded protein response. PGC-1α protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
- Molecular Weight
- 91 kDa
- Gene ID
- 19017
- NCBI Accession
- NP_001317680
- UniProt
- Q9UBK2
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