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SARS-CoV-2 Spike antibody Primary Antibody

Reactivity: SARS Coronavirus-2 (SARS-CoV-2) ELISA, FACS, ICC, IF, IHC (p), IP Host: Rabbit Monoclonal
Catalog No. ABIN6952495
$691.90
Plus shipping costs $45.00
50 μL
local_shipping Shipping to: United States
Delivery in 8 to 11 Business Days
  • Target
    Reactivity
    SARS Coronavirus-2 (SARS-CoV-2)
    Host
    Rabbit
    Clonality
    Monoclonal
    Application
    ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
    Characteristics
    2019-nCoV CoV spike/S Has cross-reactivity in ELISA with SARS Coronavirus Spike Protein (S1 Subunit), SARS Coronavirus Spike RBD
  • Application Notes
    ELISA 1:5000-1:10000
    Validated Applications:ELISA,IHC-P,FCM,ICC/IF,IP (Antibody's applications have not been validated with corresponding viruses. Optimal concentrations/dilutions should be determined by the end user.)
    Restrictions
    For Research Use only
  • Buffer
    0.2 um filtered solution in PBS
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.
  • Target
    Synonyms
    E2, Surface Glycoprotein, S
    Background
    The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, dipeptidyl peptidase-4, APN, aminopeptidase N, CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1, Sia, sialic acid, O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion, Defines the range of the hosts and specificity of the virus, Main component to bind with the neutralizing antibody, Key target for vaccine design, Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
    Gene ID
    43740568
    UniProt
    P0DTC2
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