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SARS-CoV-2 Spike Products

(SARS-CoV-2 Spike)
mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.

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Featured SARS-CoV-2 Spike Categories

SARS-CoV-2 Spike Antibodies

High quality antibodies with extensive validation data.

SARS-CoV-2 Spike Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SARS-CoV-2 Spike Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity SARS Coronavirus (SARS-CoV), SARS Coronavirus-2 (SARS-CoV-2)
Application ELISA, IF, IHC, WB
Validations
  • (10)
  • (11)
Cat. No. ABIN1030641
Quantity 0.1 mg
Datasheet Datasheet

Application ELISA, WB
Validations
  • (8)
Cat. No. ABIN6952962
Quantity 0.1 mg
Datasheet Datasheet
Reactivity SARS Coronavirus-2 (SARS-CoV-2)
Application ELISA, FACS
Validations
  • (2)
Cat. No. ABIN6964062
Quantity 100 μL
Datasheet Datasheet

Recommended SARS-CoV-2 Spike Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity SARS Coronavirus-2 (SARS-CoV-2)
Source HEK-293 Cells
Validations
  • (2)
  • (6)
Cat. No. ABIN6953302
Quantity 50 μg
Datasheet Datasheet
Reactivity SARS CoV-2 Beta, SARS Coronavirus-2 (SARS-CoV-2)
Source HEK-293 Cells
Validations
  • (2)
  • (4)
Cat. No. ABIN6963740
Quantity 100 μg
Datasheet Datasheet
Reactivity SARS Coronavirus-2 (SARS-CoV-2)
Source HEK-293 Cells
Validations
  • (5)
Cat. No. ABIN6952670
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our SARS-CoV-2 Spike products

Bohnacker, Hartung, Henkel, Quaranta, Kolmert, Priller, Ud-Dean, Giglberger, Kugler, Pechtold, Yazici, Lechner, Erber, Protzer, Lingor, Knolle, Chaker, Schmidt-Weber, Wheelock, Esser-von Bieren: "Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages." in: , Vol. 15, Issue 3, pp. 515-524, (2022) (PubMed).

Bhalla, Payam, Morelli, Sharma, Johnson, Thomson, Jolly, Canfarotta: "Nanoplasmonic biosensor for rapid detection of multiple viral variants in human serum." in: Sensors and actuators. B, Chemical, Vol. 365, pp. 131906, (2022) (PubMed).

Vogt, Augusto, Martina, Chang, Nasrallah, Speiser, Vogel, Bachmann, Mohsen: "Increased Receptor Affinity and Reduced Recognition by Specific Antibodies Contribute to Immune Escape of SARS-CoV-2 Variant Omicron." in: Vaccines, Vol. 10, Issue 5, (2022) (PubMed).

Wu, Wu, Wang, Liu, Chu, Jiang, Kwong, Chow, Li, Chen: "Microfluidic particle dam for direct visualization of SARS-CoV-2 antibody levels in COVID-19 vaccinees." in: Science advances, Vol. 8, Issue 22, pp. eabn6064, (2022) (PubMed).

Arunachalam, Feng, Ashraf, Hu, Walls, Edara, Zarnitsyna, Aye, Golden, Miranda, Green, Threeton, Maness, Beddingfield, Bohm, Scheuermann, Goff, Dufour, Russell-Lodrigue, Kepl, Fiala, Wrenn et al.: "Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine. ..." in: Science translational medicine, Vol. 14, Issue 658, pp. eabq4130, (2022) (PubMed).

Yokoyama, Ichiki: "Nano-size dependence in the adsorption by the SARS-CoV-2 spike protein over gold colloid." in: Colloids and surfaces. A, Physicochemical and engineering aspects, Vol. 615, pp. 126275, (2021) (PubMed).

Philip, Patton: "Rotavirus as an Expression Platform of the SARS-CoV-2 Spike Protein." in: bioRxiv : the preprint server for biology, (2021) (PubMed).

El Jamal, Pujadas, Ramos, Bryce, Grimes, Amanat, Tsankova, Mussa, Olson, Salem, Miorin, Aydillo, Schotsaert, Albrecht, Liu, Marjanovic, Francoeur, Sebra, Sealfon, García-Sastre, Fowkes, Cordon-Cardo et al.: "Tissue-Based SARS-Cov-2 Detection in Fatal COVID-19 Infections: Sustained Direct Viral-Induced Damage is Not Necessary to Drive Disease Progression. ..." in: Human pathology, (2021) (PubMed).

Alves Ferreira-Bravo, DeStefano: "Xeno-Nucleic Acid (XNA) 2'-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor-Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding." in: Viruses, Vol. 13, Issue 10, (2021) (PubMed).

Garifullina, Shen: "High-throughput fabrication of high aspect ratio Ag/Al nanopillars for optical detection of biomarkers." in: Journal of materials chemistry. B, (2021) (PubMed).

Synonyms and alternative names related to SARS-CoV-2 Spike

E2 glycoprotein precursor (S), Surface Glycoprotein (S), E2

Protein level used designations for SARS-CoV-2 Spike

  • spike glycoprotein
  • Peplomer protein
  • S Protein
  • S glycoprotein
  • S-Protein
  • Spike
  • Spike Protein
  • Spike glycoprotein
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