PCSK5 antibody

Catalog No. ABIN7004184

Product Details anti-PCSK5 Antibody

Target: PCSK5 (Proprotein Convertase Subtilisin/kexin Type 5 (PCSK5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCSK5 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Fusion protein of human PCSK5

Isotype: IgG

Application Details

Application Notes: IHC 1:30-1:150, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.6 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PCSK5

Target: PCSK5 (Proprotein Convertase Subtilisin/kexin Type 5 (PCSK5))

Alternative Name: PCSK5 (PCSK5 Products)

Synonyms: PC5 antibody, PC6 antibody, PC6A antibody, SPC6 antibody, subtilase antibody, PC5/6A antibody, PC5A antibody, b2b1549Clo antibody, b2b585Clo antibody, Pc5 antibody, fur2 antibody, spc6 antibody, spc6A antibody, MGC98915 antibody, PCSK5 antibody, pc6 antibody, spc6a antibody, pcsk5 antibody, zgc:165659 antibody, proprotein convertase subtilisin/kexin type 5 antibody, proprotein convertase subtilisin/kexin type 5 S homeolog antibody, proprotein convertase subtilisin/kexin type 5b antibody, PCSK5 antibody, Pcsk5 antibody, pcsk5.S antibody, LOC528098 antibody, pcsk5 antibody, pcsk5b antibody

Background: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B).

UniProt: Q92824

Pathways: Neurotrophin Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones