Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

EPH Receptor A6 antibody (Extracellular)

Epha6 Reactivity: Rat WB, IHC, IF (cc), LCI Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7043125
  • Target See all EPH Receptor A6 (Epha6) Antibodies
    EPH Receptor A6 (Epha6)
    Binding Specificity
    • 15
    • 8
    • 7
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 482-495, Extracellular
    Reactivity
    • 55
    • 30
    • 18
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat
    Host
    • 51
    • 5
    • 1
    Rabbit
    Clonality
    • 52
    • 5
    Polyclonal
    Conjugate
    • 25
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This EPH Receptor A6 antibody is un-conjugated
    Application
    • 38
    • 25
    • 17
    • 13
    • 13
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (Cultured Cells) (IF (cc)), Live Cell Imaging (LCI)
    Purpose
    A Rabbit Polyclonal Antibody to EphA6 Receptor
    Specificity
    Extracellular, N-terminus
    Cross-Reactivity
    Human, Mouse, Rat
    Predicted Reactivity
    Mouse,human - identical
    Characteristics
    Anti-EphA6 (extracellular) Antibody (ABIN7043125, ABIN7044247 and ABIN7044248)) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, indirect live cell flow cytometry, and immunohistochemistry applications. It has been designed to recognize EphA6 from rat, mouse, and human samples.
    Purification
    Affinity purified on immobilized antigen.
    Immunogen

    Immunogen: Synthetic peptide

    Immunogen Sequence: (C)KEHEQLTYSSTRSK, corresponding to amino acid residues 482-495 of rat EphA6

    Isotype
    IgG
    Top Product
    Discover our top product Epha6 Primary Antibody
  • Application Notes

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

    Application Dilutions Western blot wb: 1:200-1:400

    Comment

    Negative Control: BLP-ER016

    Blocking Peptide: BLP-ER016

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4
    Storage
    4 °C,-20 °C
    Storage Comment

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • Target
    EPH Receptor A6 (Epha6)
    Alternative Name
    EPHA6 (Epha6 Products)
    Background
    Ephrin type-A receptor 6, EPH receptor A6, EPH homology kinase 2, EHK-2,EphA6 is an erythropoietin-producing hepatocellular (Eph) receptor that belongs to the tyrosine kinase receptor family. The Eph receptor family consists of 9 EphA receptors and 5 EphB receptors, which serve key roles in normal physiology, including cell migration, cell adhesion, cell proliferation and neuronal synaptic plasticity. These activities depend on the binding of their Eph receptor-interacting (ephrin) proteins, of which include 8 members. Compelling data has demonstrated that Eph receptors and ephrins affect tumor growth, invasiveness, angiogenesis and metastasis1. They are also involved in brain development, learning and memory2.EphA6 signaling pathways are inhibitory for developing axons and blocking these pathways enhances regeneration following spinal cord and brain injury, rendering EphA6 an appealing drug target3.Eph receptors contain an extracellular structure consisting of an ephrin binding domain, the juxtamembrane region connects the extracellular portion of the receptor to the intracellular kinase domain. Two Tyrosine residues on the juxtamembrane region mediate autophosphorylation and receptor dimerization mediates the formation of heterocomplexes that are required for signaling4.

    Alternative names: Ephrin type-A receptor 6, EPH receptor A6, EPH homology kinase 2, EHK-2
    Gene ID
    29202
    NCBI Accession
    NM_001080448
    UniProt
    P54758
    Pathways
    RTK Signaling
You are here:
Support