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Neurotrophin 4 antibody (Intracellular)

NTF4 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7043393
  • Target See all Neurotrophin 4 (NTF4) Antibodies
    Neurotrophin 4 (NTF4)
    Binding Specificity
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 43-52, AA 123-132, Intracellular
    Reactivity
    • 57
    • 16
    • 11
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 36
    • 10
    • 6
    • 4
    • 2
    Rabbit
    Clonality
    • 50
    • 8
    Polyclonal
    Conjugate
    • 35
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This Neurotrophin 4 antibody is un-conjugated
    Application
    • 32
    • 29
    • 11
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Purpose
    A Rabbit Polyclonal Antibody to Neurotrophin 4
    Specificity
    Intracellular
    Cross-Reactivity
    Human, Mouse, Rat
    Predicted Reactivity
    Rat - identical
    Characteristics
    Anti-Neurotrophin 4 Antibody is directed against an epitope of human Neurotrophin 4. Anti-Neurotrophin 4 Antibody (ABIN7043393 and ABIN7044750) can be used in western blot and immunohistochemistry applications. It has been designed to recognize from rat, mouse and human samples.
    Purification
    Affinity purified on immobilized antigen.
    Immunogen

    Immunogen: Synthetic peptide

    Immunogen Sequence: LGEVPAAGGSPL(C), corresponding to amino acid residues 43-52 of mature human NT-4 (residues 123-132 of the precursor NT-4) 

    Isotype
    IgG
    Top Product
    Discover our top product NTF4 Primary Antibody
  • Application Notes

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

    Application Dilutions Western blot wb: 1:200

    Comment

    Cited Application: IFC

    Negative Control: (ABIN7566010)

    Blocking Peptide: (ABIN7566010)

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4
    Storage
    4 °C,-20 °C
    Storage Comment

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • Target
    Neurotrophin 4 (NTF4)
    Alternative Name
    NTF4 (NTF4 Products)
    Background
    NTF4, Neutrophic factor 4, Neurotrophin 5, NT-5, NTF5, Neutrophic factor 5, NT 4/5,The neurotrophins ("neuro" meaning nerve and "trophe" meaning nutrient) are a family of soluble, basic growth factors which regulate neuronal development, maintenance, survival and death in the CNS and PNS.1 Neurotrophin-4 (NT-4) is expressed in neurons of the superior cervical, stellate and celiac ganglion,2 T-cells3 and is synthesized by keratinocytes.4 The structural hallmark of all neurotrophins is the characteristic arrangement of the disulfide bridges, known as the cysteine knot, which has been found in other growth factors such as PDGF.5 The rat and human forms of NT-4 are 96 % homologous. NT-4 has been shown to promote dendritic outgrowth and calcium currents in cultured mesencephalic dopamine neurons,6 to promote growth and remodeling of adult motor neuron innervation,7 to be anterograde survival factors for postsynaptic cells8 and to protect against apoptotic neuronal death.9 The biological effects of NT-4 are mediated by two receptors: TrkB, which is specific for NT-4 and BDNF, and p75NTR, which binds all the neurotrophins.10

    Alternative names: Neurotrophin 4 (NT-4), NTF4, Neutrophic factor 4, Neurotrophin 5, NT-5, NTF5, Neutrophic factor 5, NT 4/5
    Gene ID
    16485
    NCBI Accession
    NM_006179
    UniProt
    P34130
    Pathways
    RTK Signaling
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