STOML2 antibody (Intracellular)

Catalog No. ABIN7043779

Product Details anti-STOML2 Antibody

Target: STOML2 (Stomatin (EPB72)-Like 2 (STOML2))

Binding Specificity: AA 208-222, Intracellular

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STOML2 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: A Rabbit Polyclonal Antibody to Stomatin-like Protein 2

Specificity: Intracellular

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Mouse,human - identical

Characteristics: Anti-STOML2/SLP-2 Antibody (ABIN7043779, ABIN7044518 and ABIN7044519)) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize Stomatin-like protein 2 from human, rat, and mouse samples.

Purification: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)EGTRESAINVAEGKK, corresponding to amino acid residues 208-222 of rat Stomatin-like protein 2

Isotype: IgG

Application Details

Application Notes:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:400-1:800

Comment:

Negative Control: BLP-IP002

Blocking Peptide: BLP-IP002

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Storage: 4 °C,-20 °C

Storage Comment:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Details for STOML2

Target: STOML2 (Stomatin (EPB72)-Like 2 (STOML2))

Alternative Name: STOML2 (STOML2 Products)

Background: Paraprotein target 7, EPB72-like protein 2, Stomatin-like protein 2,Stomatin-like protein 2 (STOML2, SLP-2) is a key protein on the mitochondrial inner membrane and a member of the stomatin superfamily. STOML2 is widely expressed in human tissues such as the brain, lung, and kidneys and interacts with prohibitin-1 and 2. It plays an important role in numerous physiological processes including organizing sphingolipid and cholesterol-rich lipid rafts, regulating ion channel conductance, and linking other integral membrane proteins to the peripheral cytoskeleton1,2.STOML2 shares a consensus stomatin signature sequence that defines the stomatin gene family. However, it lacks a NH2-terminal hydrophobic domain shared by other members3.Studies show that STOML2 expression is upregulated in various human cancer tissues including gastric cancer, endometrial adenocarcinoma, and breast cancer. The protein may play an important role in the incidence and development of tumor and it is suggested that SLP-2 is a potential oncogene. Knockdown of STOML2 protein significantly restrains the viability, migration, and invasion of hepatoma cell line1,2.

Alternative names: STOML2/SLP-2, Paraprotein target 7, EPB72-like protein 2, Stomatin-like protein 2

Gene ID: 298203

NCBI Accession: NM_013442

UniProt: Q4FZT0

Pathways: SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection