Recombinant NPC1L1 antibody

Catalog No. ABIN7127645

Product Details anti-NPC1L1 Antibody

Target: NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This NPC1L1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human NPC1L1

Clone: 4B10

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NPC1L1

Target: NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))

Alternative Name: NPC1L1 (NPC1L1 Products)

Background:

Background: Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.

Aliases: NPC1-like intracellular cholesterol transporter 1 (Niemann-Pick C1-like protein 1), NPC1L1

UniProt: Q9UHC9