NPC1L1 antibody (AA 1030-1100)

Catalog No. ABIN6144760

This Rabbit Polyclonal antibody specifically detects NPC1L1 in WB. It exhibits reactivity toward Human.

Quick Overview for NPC1L1 antibody (AA 1030-1100) (ABIN6144760)

Target: NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPC1L1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NPC1L1 Antibody

Binding Specificity: AA 1030-1100

Sequence: AAYSTSVNLT SDGQVLASRF MAYHKPLKNS QDYTEALRAA RELAANITAD LRKVPGTDPA FEVFPYTITN V

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1030-1100 of human NPC1L1 (NP_001095118.1).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:4000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NPC1L1

Target: NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))

Alternative Name: NPC1L1

Background: The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.,NPC1L1,NPC11L1,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Neuroscience,Cardiovascular,Heart,Lipids,Cardiovascular diseases,Heart disease,NPC1L1

Molecular Weight: 79 kDa/140 kDa/145 kDa/148 kDa

Gene ID: 29881

UniProt: Q9UHC9