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Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Subcellular location: Intracellular
Synonyms: LDLCQ3, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase, HMGCR