PSMD4/ASF antibody (Regulatory Subunit 4)

Catalog No. ABIN7142212

Product Details anti-PSMD4/ASF Antibody

Target: PSMD4/ASF (Psmd4) (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 4 (Psmd4))

Binding Specificity: AA 161-377, Regulatory Subunit 4

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMD4/ASF antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human 26S proteasome non-ATPase regulatory subunit 4 protein (161-377AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PSMD4/ASF

Target: PSMD4/ASF (Psmd4) (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 4 (Psmd4))

Alternative Name: PSMD4 (Psmd4 Products)

Background:

Background: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains.

Aliases: 26S protease subunit S5a antibody, 26S proteasome non ATPase regulatory subunit 4 antibody, 26S proteasome non-ATPase regulatory subunit 4 antibody, 26S proteasome regulatory subunit rpn10 antibody, 26S proteasome regulatory subunit S5A antibody, AF 1 antibody, AF antibody, AF1 antibody, Angiocidin antibody, Antisecretory factor 1 antibody, ASF antibody, DS5a antibody, MCB 1 antibody, MCB1 antibody, Multiubiquitin chain binding protein antibody, Multiubiquitin chain-binding protein antibody, OTTHUMP00000059963 antibody, Prosome macropain antibody, Proteasome (prosome macropain) 26S subunit non ATPase 4 antibody, Proteasome 19S S5A antibody, Proteasome 26S non ATPase subunit 4 antibody, Proteasome 26S subunit non ATPase 4 antibody, PSMD 4 antibody, Psmd4 antibody, PSMD4_HUMAN antibody, pUB R5 antibody, pUBR5 antibody, Rpn 10 antibody, Rpn10 antibody, RPN10 homolog antibody, S5A antibody, S5a/antisecretory factor protein antibody

UniProt: P55036

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway