DNAJC1 antibody (AA 521-793)

Catalog No. ABIN7150537

Product Details anti-DNAJC1 Antibody

Target: DNAJC1 (DnaJ (Hsp40) Homolog, Subfamily C, Member 1 (DNAJC1))

Binding Specificity: AA 521-793

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNAJC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Rat

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human DnaJ homolog subfamily C member 10 protein (521-793AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DNAJC1

Target: DNAJC1 (DnaJ (Hsp40) Homolog, Subfamily C, Member 1 (DNAJC1))

Alternative Name: DNAJC1 (DNAJC1 Products)

Background:

Background: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.

Aliases: DNAJC10 antibody, ERDJ5 antibody, UNQ495/PRO1012DnaJ homolog subfamily C member 10 antibody, EC 1.8.4.- antibody, Endoplasmic reticulum DNA J domain-containing protein 5 antibody, ER-resident protein ERdj5 antibody, ERdj5 antibody, Macrothioredoxin antibody, MTHr antibody

UniProt: Q8IXB1

Pathways: Chromatin Binding