DNAJC1 antibody (AA 521-793) (HRP)

Catalog No. ABIN7150540

Product Details anti-DNAJC1 Antibody (HRP)

Target: DNAJC1 (DnaJ (Hsp40) Homolog, Subfamily C, Member 1 (DNAJC1))

Binding Specificity: AA 521-793

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNAJC1 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human DnaJ homolog subfamily C member 10 protein (521-793AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DNAJC1

Target: DNAJC1 (DnaJ (Hsp40) Homolog, Subfamily C, Member 1 (DNAJC1))

Alternative Name: DNAJC1 (DNAJC1 Products)

Synonyms: dnajc1l antibody, zgc:152779 antibody, DNAJL1 antibody, ERdj1 antibody, HTJ1 antibody, MTJ1 antibody, 4733401K02Rik antibody, AA960110 antibody, D230036H06Rik antibody, Dnajl1 antibody, ERj1p antibody, DnaJ heat shock protein family (Hsp40) member C1 antibody, DnaJ (Hsp40) homolog, subfamily C, member 1 antibody, DnaJ heat shock protein family (Hsp40) member C1 S homeolog antibody, dnajc1 antibody, DNAJC1 antibody, Dnajc1 antibody, dnajc1.S antibody

Background:

Background: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.

Aliases: DNAJC10 antibody, ERDJ5 antibody, UNQ495/PRO1012DnaJ homolog subfamily C member 10 antibody, EC 1.8.4.- antibody, Endoplasmic reticulum DNA J domain-containing protein 5 antibody, ER-resident protein ERdj5 antibody, ERdj5 antibody, Macrothioredoxin antibody, MTHr antibody

UniProt: Q8IXB1

Pathways: Chromatin Binding