PIK3R6 antibody (Regulatory Subunit 6)

Catalog No. ABIN7163299

Product Details anti-PIK3R6 Antibody

Target: PIK3R6 (Phosphoinositide-3-Kinase, Regulatory Subunit 6 (PIK3R6))

Binding Specificity: AA 566-667, Regulatory Subunit 6

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIK3R6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Phosphoinositide 3-kinase regulatory subunit 6 protein (566-667AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PIK3R6

Target: PIK3R6 (Phosphoinositide-3-Kinase, Regulatory Subunit 6 (PIK3R6))

Alternative Name: PIK3R6 (PIK3R6 Products)

Background:

Background: Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis, signaling seems to involve RRAS.

Aliases: C17orf38 antibody, Chromosome 17 open reading frame 38 antibody, HsT41028 antibody, p84 PI3K adapter protein antibody, p84 PIKAP antibody, p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein antibody, p87 PI3K adapter protein antibody, p87PIKAP antibody, Phosphatidylinositol 3-kinase, regulatory subunit 6 antibody, Phosphoinositide 3-kinase gamma adapter protein of 87 kDa antibody, Phosphoinositide 3-kinase regulatory subunit 6 antibody, PI3Kgamma adapter protein of 87 kDa antibody, PI3R6_HUMAN antibody, PIK3R6 antibody

UniProt: Q5UE93

Pathways: PI3K-Akt Signaling, Inositol Metabolic Process