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PSME4 antibody (AA 105-198) (FITC)

PSME4 Reactivity: Human Host: Rabbit Polyclonal FITC
Catalog No. ABIN7164925
$328.90
Plus shipping costs $45.00
Shipping to: United States
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  • Target See all PSME4 Antibodies
    PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))
    Binding Specificity
    • 3
    • 1
    • 1
    • 1
    AA 105-198
    Reactivity
    • 7
    • 2
    • 2
    Human
    Host
    • 7
    Rabbit
    Clonality
    • 7
    Polyclonal
    Conjugate
    • 5
    • 1
    • 1
    This PSME4 antibody is conjugated to FITC
    Application
    Please inquire
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Proteasome activator complex subunit 4 protein (105-198AA)
    Isotype
    IgG
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))
    Alternative Name
    PSME4 (PSME4 Products)
    Synonyms
    proteasome activating protein 200 antibody, Afu4g11290 antibody, An04g05320 antibody, AO090003001091 antibody, PA200 antibody, AA409398 antibody, AU041366 antibody, TEMO antibody, mKIAA0077 antibody, proteasome activator subunit 4 antibody, proteasome activating protein 200 antibody, proteasome (prosome, macropain) activator subunit 4 antibody, PSME4 antibody, Psme4 antibody, PA200 antibody, AFUA_4G11290 antibody, ANI_1_888184 antibody, AOR_1_1944154 antibody, TERG_07227 antibody, psme4 antibody
    Background

    Background: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.

    Aliases: KIAA0077 antibody, PA200 antibody, Proteasome Activator 200 kDa antibody, Proteasome activator complex subunit 4 antibody, Proteasome activator PA200 antibody, PSME 4 antibody, psme4 antibody, PSME4_HUMAN antibody

    UniProt
    Q14997
    Pathways
    DNA Replication, Synthesis of DNA
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