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CBFA2T3 antibody (AA 39-159) (Biotin)

CBFA2T3 Reactivity: Human ELISA Host: Rabbit Polyclonal Biotin
Catalog No. ABIN7165195
$328.90
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  • Target See all CBFA2T3 Antibodies
    CBFA2T3 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3))
    Binding Specificity
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 39-159
    Reactivity
    • 21
    • 7
    • 4
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 19
    • 2
    Rabbit
    Clonality
    • 19
    • 2
    Polyclonal
    Conjugate
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CBFA2T3 antibody is conjugated to Biotin
    Application
    • 8
    • 7
    • 4
    • 1
    • 1
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Protein CBFA2T3 protein (39-159AA)
    Isotype
    IgG
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    CBFA2T3 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3))
    Alternative Name
    CBFA2T3 (CBFA2T3 Products)
    Synonyms
    A630044F12Rik antibody, AI465270 antibody, AW229127 antibody, Cbfa2t3h antibody, ETO-2 antibody, Eto2 antibody, MTGR2 antibody, MTG16a antibody, MTG16b antibody, ETO2 antibody, MTG16 antibody, ZMYND4 antibody, core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) antibody, CBFA2/RUNX1 translocation partner 3 antibody, Cbfa2t3 antibody, CBFA2T3 antibody
    Background

    Background: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A, interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665).

    Aliases: Cbfa2t3 antibody, Ccore binding factor runt domain alpha subunit 2 translocated to 3 antibody, ETO2 antibody, hMTG16 antibody, hMTG16a antibody, hMTG16b antibody, MTG16 antibody, MTG16_HUMAN antibody, MTG8 related gene 2 antibody, MTG8 related protein MTG16a antibody, MTG8 related protein MTG16b antibody, MTG8-related protein 2 antibody, MTGR2 antibody, Myeloid translocation gene 8 and 16b antibody, Myeloid translocation gene on chromosome 16 protein antibody, Protein CBFA2T3 antibody, Zinc finger MYND domain-containing protein 4 antibody, ZMYND4 antibody

    UniProt
    O75081
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