SLC22A17 antibody (AA 1-99)

Catalog No. ABIN7170140

Product Details anti-SLC22A17 Antibody

Target: SLC22A17 (Solute Carrier Family 22 (Organic Cation Transporter), Member 17 (SLC22A17))

Binding Specificity: AA 1-99

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC22A17 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Solute carrier family 22 member 17 protein (1-99AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:100-1:500, IF:1:50-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SLC22A17

Target: SLC22A17 (Solute Carrier Family 22 (Organic Cation Transporter), Member 17 (SLC22A17))

Alternative Name: SLC22A17 (SLC22A17 Products)

Background:

Background: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.

Aliases: 24p3 receptor antibody, 24p3R antibody, BOCT antibody, BOIT antibody, Brain type organic cation transporter antibody, Brain-type organic cation transporter antibody, hBOIT antibody, Lipocalin-2 receptor antibody, Neutrophil gelatinase associated lipocalin receptor antibody, Neutrophil gelatinase-associated lipocalin receptor antibody, NGAL receptor antibody, NgalR antibody, NGALR2 antibody, NGALR3 antibody, OTTHUMP00000082690 antibody, OTTHUMP00000082691 antibody, Potent brain type organic ion transporter antibody, S22AH_HUMAN antibody, Slc22a17 antibody, Solute carrier family 22 member 17 antibody, Solute carrier family 22 organic cation transporter member 17 antibody

UniProt: Q8WUG5

Pathways: Transition Metal Ion Homeostasis