RAP1 antibody (AA 1-280)

Catalog No. ABIN7171737

Product Details anti-RAP1 Antibody

Target: RAP1 (TERF2IP) (Telomeric Repeat Binding Factor 2, Interacting Protein (TERF2IP))

Binding Specificity: AA 1-280

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAP1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Telomeric repeat-binding factor 2-interacting protein 1 protein (1-280AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RAP1

Target: RAP1 (TERF2IP) (Telomeric Repeat Binding Factor 2, Interacting Protein (TERF2IP))

Alternative Name: TERF2IP (TERF2IP Products)

Background:

Background: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5\\\'-TTAGGG-3\\\' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5\\\'-TTAGGG-3\\\' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.

Aliases: Dopamine receptor interacting protein 5 antibody, Dopamine receptor-interacting protein 5 antibody, DRIP 5 antibody, DRIP5 antibody, hRap1 antibody, MGC105533 antibody, RAP 1 antibody, RAP1 homolog antibody, RAP1, yeast, homolog if antibody, RAP1, yeast, homolog of antibody, Repressor/activator protein 1 homolog antibody, TE2IP_HUMAN antibody, Telomeric Repeat Binding Factor 2 Interacting Protein antibody, Telomeric repeat-binding factor 2-interacting protein 1 antibody, TERF2-interacting protein antibody, TERF2-interacting telomeric protein 1 antibody, TERF2IP antibody, TRF2 Interacting Telomeric Protein RAP1 antibody, TRF2 interacting telomeric RAP1 protein antibody, TRF2-interacting telomeric protein 1 antibody, TRF2-interacting telomeric protein antibody

UniProt: Q9NYB0

Pathways: Cell Division Cycle, Telomere Maintenance