PTPRJ antibody (AA 36-210)

Catalog No. ABIN7193257

Product Details anti-PTPRJ Antibody

Target: PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))

Binding Specificity: AA 36-210

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PTPRJ antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Purpose: CD148 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human CD148 (AA: 36-210) expressed in E. Coli.

Clone: 6F2E12

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for PTPRJ

Target: PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))

Alternative Name: CD148 (PTPRJ Products)

Background:

Description:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.

Aliases: PTPRJ, DEP1, SCC1, HPTPeta, R-PTP-ETA

Molecular Weight: 146kDa

Gene ID: 5795

UniProt: Q12913

Pathways: EGFR Signaling Pathway, Platelet-derived growth Factor Receptor Signaling