PTPRJ antibody (AA 140-370)

Catalog No. ABIN7167504

Product Details anti-PTPRJ Antibody

Target: PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))

Binding Specificity: AA 140-370

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPRJ antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Receptor-type tyrosine-protein phosphatase eta protein (140-370AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PTPRJ

Target: PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))

Alternative Name: PTPRJ (PTPRJ Products)

Synonyms: HAAP antibody, CD148 antibody, DEP1 antibody, HPTPeta antibody, R-PTP-ETA antibody, SCC1 antibody, AI450271 antibody, BET antibody, Byp antibody, DEP-1 antibody, PTPbeta2 antibody, Ptpb2 antibody, RPTPJ antibody, Scc-1 antibody, Scc1 antibody, PTPRJ antibody, acid phosphatase 1 antibody, protein tyrosine phosphatase, receptor type J antibody, protein tyrosine phosphatase, receptor type, J antibody, ACP1 antibody, PTPRJ antibody, Ptprj antibody, EUBREC_2762 antibody

Background:

Background: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration, through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation, through KDR dephosphorylation. Negative regulator of EGFR signaling pathway, through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.

Aliases: CD 148 antibody, CD148 antibody, CD148 antigen antibody, Density enhanced phosphatase 1 antibody, Density-enhanced phosphatase 1 antibody, DEP 1 antibody, DEP-1 antibody, HPTP eta antibody, HPTPeta antibody, Human density enhanced phosphatase 1 antibody, Protein tyrosine phosphatase eta antibody, Protein tyrosine phosphatase receptor type J antibody, Protein tyrosine phosphatase receptor type J polypeptide antibody, Protein-tyrosine phosphatase eta antibody, Protein-tyrosine phosphatase receptor type J antibody, PTPJ antibody, Ptprj antibody, PTPRJ_HUMAN antibody, R PTP Eta antibody, R-PTP-eta antibody, R-PTP-J antibody, Receptor type tyrosine protein phosphatase eta antibody, Receptor-type tyrosine-protein phosphatase eta antibody, SCC 1 antibody, SCC1 antibody, susceptibility to colon cancer 1, mouse, homolog of antibody

UniProt: Q12913

Pathways: EGFR Signaling Pathway, Platelet-derived growth Factor Receptor Signaling